9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Base Information

Chemical Name:9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine
CAS No.:478161-11-4
Molecular Formula:C₂₂H₂₉N₇O₃
Molecular Weight:439.517
Hs Code.:

Synonyms:9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

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Chemical Property of 9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

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Technology Process of 9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

There total 4 articles about 9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 478161-09-0
2-({[(3aR,4R,6R,6aR)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-methyl-amino}-methyl)-benzonitrile

: 478161-11-4
9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm0201621

Reference yield:

: 362-75-4
2',3'-isopropylidene adenosine

: 478161-11-4
9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: 0.392 g / Heating

3: 77 percent / K₂CO₃; NaI / acetonitrile / 18 h / Heating

4: 28 percent / LiAlH₄ / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; sodium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm0201621

Reference yield:

: 24514-56-5
9-((3aR,4R,6S,6aS)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

: 478161-11-4
9-((3aR,4R,6R,6aR)-6-{[(2-Aminomethyl-benzyl)-methyl-amino]-methyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 0.392 g / Heating

2: 77 percent / K₂CO₃; NaI / acetonitrile / 18 h / Heating

3: 28 percent / LiAlH₄ / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; sodium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm0201621