Cyclohexanecarboxylic acid, 1-amino-2-hydroxy-, (1R,2S)- (9CI)

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 1-amino-2-hydroxy-, (1R,2S)- (9CI)
• CAS No.: 197247-91-9
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.185
• Mol file: 197247-91-9.mol

Synonyms:Cyclohexanecarboxylicacid, 1-amino-2-hydroxy-, (1R-cis)-;cis-(1R,2S)-1-Amino-2-hydroxycyclohexanecarboxylic acid

Chemical Property of Cyclohexanecarboxylic acid, 1-amino-2-hydroxy-, (1R,2S)- (9CI)

Chemical Property:

• PSA: 83.55000
• LogP: 0.40370

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxylic acid, 1-amino-2-hydroxy-, (1R,2S)- (9CI)

There total 11 articles about Cyclohexanecarboxylic acid, 1-amino-2-hydroxy-, (1R,2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3S,4aS)-3-Benzyl-2-oxo-hexahydro-benzo[1,4]oxazine-4a-carbonitrile → (R)-1-Amino-2-hydroxy-cyclohexanecarboxylic acid (197247-92-0,197247-91-9,226905-10-8,64513-81-1)

Guidance literature:

(3S,4aS)-3-Benzyl-2-oxo-hexahydro-benzo[1,4]oxazine-4a-carbonitrile; With ozone; In ethyl acetate; at -78 ℃; for 0.5h;

With oxonium;

DOI:10.1016/S0040-4039(01)00551-2

Reference yield: 92.0%

C16H16N2O2 (197247-85-1) → cis-(1R,2S)-1-amino-2-hydroxycyclohexanecarboxylic acid (197247-91-9,197247-92-0,226905-10-8,64513-81-1)

Guidance literature:

With hydrogenchloride; at 110 ℃; for 14h;

DOI:10.1246/bcsj.79.768

Reference yield: 90.0%

(1S,3S,6R)-2-aza-3-(t-butyl)-5-oxa-4-oxobicyclo[4.4.0]decane-1-carbonitrile (355134-30-4) → trans-(1R,2R)-1-amino-2-hydroxycyclohexanecarboxylic acid (197247-91-9,197247-92-0,226905-10-8,64513-81-1)

Guidance literature:

(1S,3S,6R)-2-aza-3-(t-butyl)-5-oxa-4-oxobicyclo[4.4.0]decane-1-carbonitrile; With ozone; In ethyl acetate; at -78 ℃; for 0.416667h;

With oxonium;

DOI:10.1016/S0040-4039(01)00551-2

upstream raw materials:

(1S,3S,6R)-2-aza-3-(t-butyl)-5-oxa-4-oxobicyclo[4.4.0]decane-1-carbonitrile

C₁₆H₁₆N₂O₂

C₁₆H₁₈N₂O₂