(R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol

Base Information

• Chemical Name: (R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol
• CAS No.: 457897-94-8
• Molecular Formula: C₁₈H₂₂Cl₂N₂O₄S
• Molecular Weight: 433.356

Synonyms:(R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol

Chemical Property of (R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol

Chemical Property:

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Technology Process of (R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol

There total 1 articles about (R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-glycidyl N-methylsulfonyl-4-aminophenyl ether (457897-87-9) + 2-(3,4-dichlorophenyl)ethanamine (21581-45-3) → (R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol (457897-94-8)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/jm8002153

Reference yield:

(R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol (457897-94-8) + butyraldehyde (123-72-8) → (R)-1-(4-methanesulfonamidophenoxy)-3-(N-butyl-3,4-dichlorophenylethylamino)-2-propanol (457898-22-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1021/jm8002153

Reference yield:

(R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol (457897-94-8) + meta-hydroxybenzaldehyde (100-83-4) → (R)-1-(4-methanesulfonamidophenoxy)-3-(N-(3-hydroxybenzyl)-3,4-dichlorophenylethylamino)-2-propanol (1060789-91-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1021/jm8002153

upstream raw materials:

(R)-glycidyl N-methylsulfonyl-4-aminophenyl ether

2-(3,4-dichlorophenyl)ethanamine

Downstream raw materials:

(R)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol hydrochloride

(R)-1-(4-methanesulfonamidophenoxy)-3-(N-(2-hydroxybenzyl)-3,4-dichlorophenylethylamino)-2-propanol

(R)-1-(4-methanesulfonamidophenoxy)-3-(N-butyl-3,4-dichlorophenylethylamino)-2-propanol

(R)-1-(4-methanesulfonamidophenoxy)-3-(N-(3-hydroxybenzyl)-3,4-dichlorophenylethylamino)-2-propanol

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