3,8-Diaza-bicyclo[3.2.1]octane

Base Information

• Chemical Name: 3,8-Diaza-bicyclo[3.2.1]octane
• CAS No.: 280-06-8
• Molecular Formula: C6H12 N2
• Molecular Weight: 112.175
• Hs Code.: 2933990090
• Mol file: 280-06-8.mol

Synonyms:3,8-Diaza-bicyclo[3.2.1]octane

Chemical Property of 3,8-Diaza-bicyclo[3.2.1]octane

Chemical Property:

• Boiling Point: 78-80 °C(Press: 40 Torr)
• PKA: 10.32±0.20(Predicted)
• PSA: 24.06000
• Density: 0.975±0.06 g/cm3(Predicted)
• LogP: 0.36780

Purity/Quality:

97% ^*data from raw suppliers

3,8-Diaza-bicyclo[3.2.1]octane 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,8-Diaza-bicyclo[3.2.1]octane

There total 1 articles about 3,8-Diaza-bicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3,8-diazabicyclo[3.2.1.]octane (280-06-8)

Guidance literature:

3,8-Diaza-bicyclo<3.2.1>octan-2-on, LiAlH4, THF (anfangs bei 0grad, zuletzt bei 60grad);

Reference yield: 82.0%

4-chloromethyl-2-(4-methoxyphenyl)pyridine + 3,8-diazabicyclo[3.2.1.]octane (280-06-8) → C6H10N2(CH2C5H3NC6H4OCH3)2

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 - 120 ℃; for 1.16667h; microwave;

DOI:10.1016/j.ejmech.2006.11.013

Reference yield: 82.0%

4-chloromethyl-2-(4-chlorophenyl)pyridine (482376-16-9) + 3,8-diazabicyclo[3.2.1.]octane (280-06-8) → C6H10N2(CH2C5H3NC6H4Cl)2

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 - 120 ℃; for 1.16667h; microwave;

DOI:10.1016/j.ejmech.2006.11.013

Refernces