2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione
CAS No.:76879-47-5
Molecular Formula:C₂₉H₂₅ClN₄O₄
Molecular Weight:528.995
Hs Code.:

Synonyms:2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione

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Chemical Property of 2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione

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Technology Process of 2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione

There total 5 articles about 2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 63200-67-9
2-[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-isoindole-1,3-dione

: 4547-02-8
7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

: 76879-47-5
2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione

: 63200-73-7
N-(2-{2-[(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-methyl]-[1,3]dioxolan-2-yl}-ethyl)-phthalimide

Guidance literature:: In ethanol; at 60 ℃;
DOI:10.1021/jo00321a010

Reference yield:

: 63200-65-7
N-<2-<2-(azidomethyl)-1,3-dioxolan-2-yl>ethyl>phthalimide

: 76879-47-5
2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 12.7 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h

2: 36 percent / ethanol / 60 °C / overnight

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jo00321a010

Reference yield:

: 63200-66-8
2-[2-(2-Bromomethyl-[1,3]dioxolan-2-yl)-ethyl]-isoindole-1,3-dione

: 76879-47-5
2-{2-[2-(7-Chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-ylamino)-ethyl]-[1,3]dioxolan-2-ylmethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / NaN₃ / dimethylsulfoxide / 18 h / 120 °C / Heating

2: 12.7 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h

3: 36 percent / ethanol / 60 °C / overnight

With sodium azide; hydrogen; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00321a010