N₂-(5-amino-2-methoxybenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(5-amino-2-methoxybenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
• CAS No.: 1346447-86-6
• Molecular Formula: C₂₁H₂₄ClN₅O₃S
• Molecular Weight: 461.972

Synonyms:N₂-(5-amino-2-methoxybenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Chemical Property of N₂-(5-amino-2-methoxybenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(5-amino-2-methoxybenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

There total 10 articles about N₂-(5-amino-2-methoxybenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine (1346447-85-5) → N2-(5-amino-2-methoxybenzyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1346447-86-6)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; at 20 ℃; for 12h;

Reference yield:

1-amino-2-(isopropylsulphonyl)benzene (76697-50-2) → N2-(5-amino-2-methoxybenzyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1346447-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

1.2: 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 100 °C

3.1: hydrogen / platinum(IV) oxide / ethyl acetate / 12 h / 20 °C

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-(isopropyl sulfanyl)nitrobenzene (70415-85-9) → N2-(5-amino-2-methoxybenzyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1346447-86-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

3.2: 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 100 °C

5.1: hydrogen / platinum(IV) oxide / ethyl acetate / 12 h / 20 °C

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; platinum(IV) oxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

ortho-nitrofluorobenzene

2-methoxy-5-nitrobenzyl bromide

2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine

para-methoxynitrobenzene

Downstream raw materials:

N-(3-(((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)methyl)-4-methoxyphenyl)acrylamide

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