Furo[3,2-b]pyridine

Base Information

• Chemical Name: Furo[3,2-b]pyridine
• CAS No.: 272-62-8
• Molecular Formula: C7H5NO
• Molecular Weight: 119.12
• Hs Code.: 2934999090
• European Community (EC) Number: 639-308-0
• DSSTox Substance ID: DTXSID10480596
• Nikkaji Number: J433.472H
• Wikidata: Q72479794
• Mol file: 272-62-8.mol

Synonyms:furo(3,2-b)pyridine

Chemical Property of Furo[3,2-b]pyridine

Chemical Property:

• Vapor Pressure: 1.263mmHg at 25°C
• Refractive Index: 1.5753 (19℃)
• Boiling Point: 179.633 °C at 760 mmHg
• PKA: 4.22±0.30(Predicted)
• Flash Point: 64.325 °C
• PSA: 26.03000
• Density: 1.196 g/cm³
• LogP: 1.82780
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 119.037113783
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

Furo[3,2-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CO2)N=C1

Technology Process of Furo[3,2-b]pyridine

There total 21 articles about Furo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-hydroxy-2,3-dihydrofuro<3,2-b>pyridine (107096-01-5) → furo[3,2-b]pyridine (272-62-8)

Guidance literature:

With phosphoric acid; at 170 - 180 ℃; for 15h;

Reference yield: 21.0%

acetic acid 2-bromopyridin-3-yl ester (92671-70-0) → furo[3,2-b]pyridine (272-62-8)

Guidance literature:

With copper(l) iodide; triethylamine; trimethylsilylacetylene; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 21.0%

3-(2-furanyl)-propenal O-methyloxime (79108-72-8) → furo[3,2-b]pyridine (272-62-8)

Guidance literature:

at 650 ℃; for 3h; under 0.01 Torr;

DOI:10.1055/s-1981-29486

upstream raw materials:

furo<3,2-b>pyridine-5-carboxylic acid

3-(2-furanyl)-propenal O-methyloxime

3-hydroxy-2,3-dihydrofuro<3,2-b>pyridine

3-bromofuro<3,2-b>pyridine

Downstream raw materials:

2-nitrofuro<3,2-b>pyridine

cis-2-nitro-2,3-dihydrofuro<3,2-b>pyridin-3-ol

trans-2-nitro-2,3-dihydrofuro<3,2-b>pyridin-3-ol

2-formylfuro<3,2-b>pyridine