2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine

Base Information

• Chemical Name: 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine
• CAS No.: 855749-20-1
• Molecular Formula: C₂₆H₂₉NO₂SSi
• Molecular Weight: 447.673
• Mol file: 855749-20-1.mol

Synonyms:2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine

Chemical Property of 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine

There total 7 articles about 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-N-(2-pent-3-en-1-ynyl-phenyl)-benzenesulfonamide (855749-00-7) + Phenyl-trimethylsilanylethynyl-iodonium → 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine (855749-20-1)

Guidance literature:

With potassium hexamethylsilazane; In toluene; at 20 ℃;

DOI:10.1021/ol050609a

Reference yield:

2-iodophenylamine (615-43-0) → 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine (855749-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1: PdCl₂(PPh₃)2; CuI; Et₃N / tetrahydrofuran / 20 °C

2: pyridine / tetrahydrofuran

3: KHMDS / toluene; CH₂Cl₂ / cooling

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 1: Sonogashira cross-coupling;

DOI:10.1016/j.tet.2005.11.082

Reference yield:

((Z)-2-Pent-3-en-1-ynyl)-phenylamine (855748-98-0) → 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine (855749-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran

2: KHMDS / toluene / 20 °C

With pyridine; potassium hexamethylsilazane; In tetrahydrofuran; toluene;

DOI:10.1021/ol050609a

upstream raw materials:

4-methyl-N-(2-pent-3-en-1-ynyl-phenyl)-benzenesulfonamide

N-(2-(cyclohex-1-en-1-ylethynyl)phenyl)-4-methylbenzenesulfonamide

1-ethenylcyclohexene

2-iodophenylamine