ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate
CAS No.:943720-95-4
Molecular Formula:C₂₇H₂₉N₅O₄
Molecular Weight:487.558
Hs Code.:

Synonyms:ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate

There total 3 articles about ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 943631-31-0
5-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butanoylamino]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

: 100-46-9
benzylamine

: 943720-95-4
ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate

Guidance literature:: 5-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butanoylamino]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester; With hexachloroethane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 4h;

benzylamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; Further stages.;
DOI:10.1016/j.tetlet.2007.04.043

Reference yield:

: 31037-02-2
ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate

: 943720-95-4
ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / diisopropylethylamine / toluene / 2 h / Heating

2.1: N,N-diisopropylethyl amine; triphenylphosphine; hexachloroethane / CH₂Cl₂ / 4 h / 20 °C

2.2: 84 percent / N,N-diisopropylethyl amine / tetrahydrofuran; CH₂Cl₂

With hexachloroethane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2007.04.043

Reference yield:

: 64404-11-1
phthalyl-DL-valine acid chloride

: 943720-95-4
ethyl 5-({(1Z)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-[(phenylmethyl)amino]butylidene}amino)-1-methyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / diisopropylethylamine / toluene / 2 h / Heating

2.1: N,N-diisopropylethyl amine; triphenylphosphine; hexachloroethane / CH₂Cl₂ / 4 h / 20 °C

2.2: 84 percent / N,N-diisopropylethyl amine / tetrahydrofuran; CH₂Cl₂

With hexachloroethane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2007.04.043