methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate
CAS No.:1384850-60-5
Molecular Formula:C₃₀H₂₇FN₄O₄
Molecular Weight:526.567
Hs Code.:

Synonyms:methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate

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Chemical Property of methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate

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Technology Process of methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate

There total 10 articles about methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1384850-60-5
methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 0.5 h / 20 °C

3.1: 3 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 110 °C

5.1: sulfuric acid / 20 °C

5.2: pH 7

6.1: 3 h / 150 °C

7.1: pyridine / dichloromethane / 20 °C

8.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

9.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / -10 °C / Inert atmosphere

10.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / 3800.26 Torr / Inert atmosphere

With pyridine; potassium phosphate; N-Bromosuccinimide; sulfuric acid; hydrogen; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1384850-60-5
methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: hydrogen / palladium on activated charcoal / methanol / 0.5 h / 20 °C

4.1: 3 h / Reflux

5.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 110 °C

6.1: sulfuric acid / 20 °C

6.2: pH 7

7.1: 3 h / 150 °C

8.1: pyridine / dichloromethane / 20 °C

9.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

10.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / -10 °C / Inert atmosphere

11.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / 3800.26 Torr / Inert atmosphere

With pyridine; potassium phosphate; N-Bromosuccinimide; thionyl chloride; sulfuric acid; hydrogen; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 234751-03-2
methyl 4-[(4-methoxybenzyl)amino]-3-nitrobenzoate

: 1384850-60-5
methyl 2-(4-fluorophenyl)-3-[6-[(morpholin-4-yl)carbonyl]-1,2,3,4-tetrahydroquinolin-1-yl]quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 0.5 h / 20 °C

2.1: 3 h / Reflux

3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 110 °C

4.1: sulfuric acid / 20 °C

4.2: pH 7

5.1: 3 h / 150 °C

6.1: pyridine / dichloromethane / 20 °C

7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

8.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / -10 °C / Inert atmosphere

9.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / 3800.26 Torr / Inert atmosphere

With pyridine; potassium phosphate; N-Bromosuccinimide; sulfuric acid; hydrogen; N,N-dimethyl-aniline; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;