N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide

Base Information

Chemical Name:N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide
CAS No.:1415114-12-3
Molecular Formula:C₂₅H₂₀N₄O₃S
Molecular Weight:456.525
Hs Code.:

Synonyms:N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide

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Chemical Property of N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide

Chemical Property:

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Technology Process of N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide

There total 9 articles about N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1415114-76-9
2-chloro-5-(isoquinolin-6-yl)oxazole

: 926203-10-3
N-(3-aminophenyl)-1-phenylmethanesulfonamide

: 1415114-12-3
N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide

Guidance literature:: In isopropyl alcohol; at 80 ℃; for 24h;

Reference yield:

: 1939-99-7
benzenesulfonyl chloride

: 1415114-12-3
N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / acetonitrile / 14 h / 10 - 20 °C

2: isopropyl alcohol / 24 h / 80 °C

With pyridine; In isopropyl alcohol; acetonitrile;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1415114-12-3
N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / methanol / 1.5 h / Reflux

2.1: hydrogen / palladium on activated charcoal / methanol / 14 h

3.1: pyridine / 6 h / 20 °C

4.1: potassium carbonate / 18-crown-6 ether / N,N-dimethyl-formamide / 12 h / 120 °C

5.1: aluminum (III) chloride / dichloromethane / 20 °C

5.2: Cooling with ice

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: isopropyl alcohol / 24 h / 80 °C

With pyridine; aluminum (III) chloride; hydrogen; potassium carbonate; lithium hexamethyldisilazane; 18-crown-6 ether; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;