(5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline

Base Information

Chemical Name:(5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline
CAS No.:409319-32-0
Molecular Formula:C₁₉H₂₁NO
Molecular Weight:279.382
Hs Code.:

Synonyms:(5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline

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Chemical Property of (5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline

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Technology Process of (5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline

There total 2 articles about (5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 409319-31-9
(5S,8R)-(-)-5,6,7,8-tetrahydro-8,99-trimethyl-2-(2-methoxyphenyl)-5,8-methanoquinoline

: 409319-32-0
(5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(01)01002-X

Reference yield:

: 1-<2-(2-Methoxyphenyl)-2-oxyethyl>pyridinium iodide

: 409319-32-0
(5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 24 percent / ammonium acetate / acetic acid / 20 h / 140 °C

2: 85 percent / BBr₃ / CH₂Cl₂ / 0 - 20 °C

With ammonium acetate; boron tribromide; In dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)01002-X

Reference yield:

: 409319-32-0
(5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-hydroxyphenyl)-5,8-methanoquinoline

: (5S,8R)-(-)-5,6,7,8-tetrahydro-8,9,9-trimethyl-2-(2-diphenylphosphinophenyl)-5,8-methanoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

2.1: NiCl₂(dppe) / dimethylformamide / 0.5 h / 100 °C

2.2: 19 percent / 1,4-diazabicyclo[2.2.2]octane / dimethylformamide / 24 h / 100 °C

With pyridine; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)01002-X