2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine

Base Information

Chemical Name:2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine
CAS No.:1610965-41-7
Molecular Formula:C₂₁H₁₇F₃N₆O
Molecular Weight:426.401
Hs Code.:

Synonyms:2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine

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Chemical Property of 2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine

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Technology Process of 2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine

There total 5 articles about 2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1610966-69-2
C₁₆H₁₃F₃N₄O

: 25275-41-6
N-iminopyridinium ylide

: 1610965-41-7
2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 48h;

Reference yield:

: 1610966-68-1
6-chloro-2-(cyclopropylethynyl)-N-(4-(difluoromethoxy)phenyl)-5-fluoropyrimidin-4-amine

: 1610965-41-7
2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / dimethyl sulfoxide / 48 h / 100 °C / Sealed tube

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 - 80 °C

With ammonium hydroxide; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 6746-94-7
Cyclopropylacetylene

: 1610965-41-7
2-(2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)-N-[4-(difluoromethoxy)phenyl]-5-fluoropyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl magnesium chloride - lithium chloride complex / tetrahydrofuran / 0.5 h / -78 - 0 °C

2: tetrahydrofuran / -78 - 0 °C

3: ethanol / 1 h / Reflux

4: ammonium hydroxide / dimethyl sulfoxide / 48 h / 100 °C / Sealed tube

5: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 - 80 °C

With ammonium hydroxide; isopropyl magnesium chloride - lithium chloride complex; potassium carbonate; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;