(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine

Base Information

Chemical Name:(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine
CAS No.:182075-12-3
Molecular Formula:C₁₃H₁₆F₂N₄O₂S
Molecular Weight:330.358
Hs Code.:

Synonyms:(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine

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Chemical Property of (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine

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Technology Process of (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine

There total 8 articles about (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 182075-03-2
(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine

: 182075-12-3
(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine

Guidance literature:: With sulfuric acid; In chloroform; at 0 - 25 ℃; for 4h;

Reference yield:

: threo-2-(2,4-difluorophenyl)-2-(1-methylthioethyl)oxirane

: 182075-12-3
(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine

Guidance literature:: Multi-step reaction with 5 steps

1: 49 percent / dimethylformamide / 3 h / 0 - 20 °C

2: 49 percent / 1.) 96 percent aq. KOH / dimethylsulfoxide / 1.) 75 deg C, 10 min; 2.) rt, 2 h

3: 97 percent / K₂CO₃, MCPBA / dimethylformamide / 4 h / Ambient temperature

4: 73 percent / conc. H₂SO₄ / CHCl₃ / ice-cooling, 30 min; rt, 4 h

With potassium hydroxide; sulfuric acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 133775-27-6
(2R,3R)-2-(2,4-difluorophenyl)-3-(methylthio)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

: 182075-12-3
(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / methanol / Ambient temperature

2: 88 percent / MCPBA, K₂CO₃ / dimethylformamide / 1.5 h / Ambient temperature

3: 72 percent / conc. H₂SO₄ / CHCl₃ / 4 h / 0 - 25 °C

With sulfuric acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; chloroform; N,N-dimethyl-formamide;