1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester
• CAS No.: 133550-61-5
• Molecular Formula: C₁₂H₁₇BrO₃
• Molecular Weight: 289.169
• Mol file: 133550-61-5.mol

Synonyms:1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester

Chemical Property of 1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester

There total 1 articles about 1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) + 2-bromoallyl bromide (513-31-5) → 1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester (133550-61-5)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 1 h, 2.) RT, overnight;

DOI:10.1021/jo00009a032

Reference yield: 84.0%

1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester (133550-61-5) → ethyl 3-bromo-1-(2-bromo-2-propenyl)-2-oxocyclohexanecarboxylate (133550-62-6,133578-19-5)

Guidance literature:

With copper(ll) bromide; In tetrahydrofuran; for 48h; Ambient temperature;

DOI:10.1021/jo00009a032

Reference yield: 80.0%

1-(2-bromoallyl)-2-oxocyclohexanecarboxylic acid ethyl ester (133550-61-5) → 1-(3-bromo-2-oxopropyl)-2-oxocyclohexanecarboxylic acid ethyl ester

Guidance literature:

With sodium hypobromide; In acetic acid; acetone; at 0 ℃;

DOI:10.1021/jo020739m

upstream raw materials:

ethyl 2-oxocyclohexane carboxylate

2-bromoallyl bromide

Downstream raw materials:

ethyl 3-bromo-1-(2-bromo-2-propenyl)-2-oxocyclohexanecarboxylate

ethyl 1-(2-bromo-2-propenyl)-2-oxo-3-cyclohexenecarboxylate

(1S,2R)-1-(2-Bromo-allyl)-2-(naphthalen-1-ylcarbamoyloxy)-cyclohex-3-enecarboxylic acid ethyl ester

ethyl 1-allyl-2-hydroxy-3-cyclohexenecarboxylate