(S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide

Base Information

Chemical Name:(S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide
CAS No.:1265136-96-6
Molecular Formula:C₂₆H₂₃F₆N₃OS
Molecular Weight:539.545
Hs Code.:

Synonyms:(S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide

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Technology Process of (S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide

There total 5 articles about (S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: C₁₇H₂₀N₂O

: 1265136-96-6
(S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide

Guidance literature:: In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.3987/COM-10-12055

Reference yield:

: N-benzyl-N-methyl-L-phenylalaninamide trifluoroacetate

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1265136-96-6
(S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide

Guidance literature:: With triethylamine; In dichloromethane; chloroform;
DOI:10.1080/00397911.2017.1383432

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1265136-96-6
(S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 0 °C / Cooling with ice

1.2: 12 h / 0 °C

2.1: dichloromethane

3.1: triethylamine / chloroform; dichloromethane

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;
DOI:10.1080/00397911.2017.1383432