[2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate

Base Information

Chemical Name:[2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate
CAS No.:1350912-36-5
Molecular Formula:C₁₆H₁₁F₃N₂O₃S
Molecular Weight:368.336
Hs Code.:

Synonyms:[2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate

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Chemical Property of [2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate

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Technology Process of [2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate

There total 5 articles about [2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1350912-35-4
[2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methanol

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1350912-36-5
[2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate

Guidance literature:: With pyridine; In dichloromethane; at 50 ℃; for 1.5h;
DOI:10.1007/s10593-011-0823-z

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 1350912-36-5
[2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; potassium hydroxide / tetrahydrofuran / 2 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.2: -20 - 20 °C

4.1: Bromotrichloromethane / dichloromethane / -20 - 0 °C

4.2: 0 - 20 °C

5.1: sodium tetrahydroborate / methanol / 4 h / 20 °C

6.1: pyridine / dichloromethane / 1.5 h / 50 °C

With pyridine; dmap; sodium tetrahydroborate; Bromotrichloromethane; diethylamino-sulfur trifluoride; water; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1007/s10593-011-0823-z

Reference yield:

: 35272-15-2
2-methylthiazole-4-carboxylic acid

: 1350912-36-5
[2-(2-methyl-1,3-thiazol-4-yl)-1,3-oxazol-4-yl]methyl 4-trifluoromethylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.2: -20 - 20 °C

3.1: Bromotrichloromethane / dichloromethane / -20 - 0 °C

3.2: 0 - 20 °C

4.1: sodium tetrahydroborate / methanol / 4 h / 20 °C

5.1: pyridine / dichloromethane / 1.5 h / 50 °C

With pyridine; dmap; sodium tetrahydroborate; Bromotrichloromethane; diethylamino-sulfur trifluoride; triethylamine; In methanol; dichloromethane;
DOI:10.1007/s10593-011-0823-z