N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Base Information

Chemical Name:N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CAS No.:1426802-98-3
Molecular Formula:C₂₃H₁₈Cl₂N₂O₃S
Molecular Weight:473.38
Hs Code.:

Synonyms:N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Technology Process of N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

There total 2 articles about N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1426805-53-9
4'-amino-2',6'-dichloro-[1,1'-biphenyl]-2-carbonitrile

: 1426805-26-6
pentafluorophenyl [4-(ethylsulfonyl)phenyl]acetate

: 1426802-98-3
N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; for 15h;
DOI:10.1021/acsmedchemlett.5b00122

Reference yield:

: 1940-29-0
4-bromo-3,5-dichloroaniline

: 138642-62-3
2-Cyanophenylboronic acid

: 1426802-98-3
N-(2,6-dichloro-2'-cyano-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane / 0.5 h / 100 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 15 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00122