3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide

Base Information

Chemical Name:3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide
CAS No.:1147334-71-1
Molecular Formula:C₁₀H₇F₃N₂O₃
Molecular Weight:260.172
Hs Code.:

Synonyms:3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide

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Technology Process of 3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide

There total 6 articles about 3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: 180635-56-7
p-(trifluoromethyl)cinnamyl alcohol

: 1147334-71-1
3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide

Guidance literature:: With acetic acid; sodium nitrite; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 3h;

Reference yield: 36.0%

: 125617-18-7
3-(4-trifluoromethylphenyl)-2-propen-1-ol

: 1147334-71-1
3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenyl)-1,2,5-oxadiazole 2-oxide

Guidance literature:: With acetic acid; sodium nitrite; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere; Heating;
DOI:10.1021/acs.jmedchem.8b00389