5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone

Base Information

• Chemical Name: 5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone
• CAS No.: 131523-14-3
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.312
• Mol file: 131523-14-3.mol

Synonyms:5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone

Chemical Property of 5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone

There total 4 articles about 5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

5-allyloxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-12-1) → 5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-14-3)

Guidance literature:

With boron trichloride; In chlorobenzene; at -30 ℃; for 2h;

DOI:10.1248/cpb.38.2060 DOI:10.1248/cpb.47.529

Reference yield:

4-hydroxyphthalic acid (610-35-5) → 5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-14-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 59 percent / a) H₂O, 150 deg C, 1 h, b) H₂O, 190 deg C, 1 h

2: 78 percent / K₂CO₃ / acetone / 48 h / 70 °C

3: 1.) Mg / 1.) THF, 50 deg C, 1 h, 2.) THF, RT, 8 h

4: 52 percent / conc.HCl / tetrahydrofuran / 8 h / Ambient temperature

5: 46 percent / BCl₃ / chlorobenzene / 2 h / -30 °C

With hydrogenchloride; boron trichloride; potassium carbonate; magnesium; In tetrahydrofuran; chlorobenzene; acetone;

DOI:10.1248/cpb.47.529

Reference yield:

5-allyloxy-3-hydroxy-2-methyl-3-phenylethyl-1-isoindolinone (226990-55-2) → 5-hydroxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / conc.HCl / tetrahydrofuran / 8 h / Ambient temperature

2: 46 percent / BCl₃ / chlorobenzene / 2 h / -30 °C

With hydrogenchloride; boron trichloride; In tetrahydrofuran; chlorobenzene;

DOI:10.1248/cpb.47.529

upstream raw materials:

5-allyloxy-2-methyl-3-<(E)-2-phenylethylidene>-1-isoindolinone

4-hydroxyphthalic acid

5-allyloxy-3-hydroxy-2-methyl-3-phenylethyl-1-isoindolinone

phenethylmagnesium bromide