(R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Base Information

Chemical Name:(R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol
CAS No.:1437779-51-5
Molecular Formula:C₁₉H₁₄BCl₂F₄NO₃
Molecular Weight:462.036
Hs Code.:

Synonyms:(R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

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Chemical Property of (R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

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Technology Process of (R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

There total 10 articles about (R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437779-30-0
5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethyl-benzo[c][1,2]oxaborol-1(3H)-ol

: 1437779-50-4
(S)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

: 1437779-51-5
(R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: With CHIRALCEL OJ-H; In methanol; at 35 ℃; Resolution of racemate;

Reference yield:

: 2268-05-5
1,3-dichloro-2-fluorobenzene

: 1437779-50-4
(S)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

: 1437779-51-5
(R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 2-(((2,6-diisopropylphenyl)imino)methyl)pyridine; bis(1,5-cyclooctadiene)diiridium(I) dichloride / n-heptane / 18 h / Reflux

2: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 70 °C / Sealed tube

3: triethylamine / N,N-dimethyl-formamide / 12 h

4: CHIRALCEL OJ-H / methanol / 35 °C / Resolution of racemate

With bis-triphenylphosphine-palladium(II) chloride; bis(1,5-cyclooctadiene)diiridium(I) dichloride; caesium carbonate; triethylamine; 2-(((2,6-diisopropylphenyl)imino)methyl)pyridine; In tetrahydrofuran; methanol; n-heptane; N,N-dimethyl-formamide;

Reference yield:

: 1092485-88-5
2-(3,5-dichloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1437779-50-4
(S)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

: 1437779-51-5
(R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 70 °C / Sealed tube

2: triethylamine / N,N-dimethyl-formamide / 12 h

3: CHIRALCEL OJ-H / methanol / 35 °C / Resolution of racemate

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;