3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

Base Information

Chemical Name:3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate
CAS No.:250651-14-0
Molecular Formula:C₂₇H₃₄ClN₃O₁₀S₂
Molecular Weight:660.166
Hs Code.:

3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

Synonyms:3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

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Chemical Property of 3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

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Technology Process of 3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

There total 10 articles about 3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 527-60-6
Mesitol

: 250651-14-0
3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N

2: 70 percent HNO₃; conc. H₂SO₄; AcOH / 1 h

3: Fe; AcOH / 1 h / 90 - 110 °C

4: tetrahydrofuran / 20 °C

5: 552 mg / K₂CO₃ / methanol / 0.5 h

6: 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

With dmap; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1: Acetylation / 2: Nitration / 3: Reduction / 4: Acylation / 5: Deacetylation / 6: Acylation;
DOI:10.1021/jm9900063

Reference yield:

: 115231-65-7
acetic acid-(2,4,6-trimethyl-3-nitro-phenyl ester)

: 250651-14-0
3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: Fe; AcOH / 1 h / 90 - 110 °C

2: tetrahydrofuran / 20 °C

3: 552 mg / K₂CO₃ / methanol / 0.5 h

4: 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

With dmap; iron; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; 1: Reduction / 2: Acylation / 3: Deacetylation / 4: Acylation;
DOI:10.1021/jm9900063

Reference yield:

: 19082-49-6
mesityl acetate

: 250651-14-0
3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent HNO₃; conc. H₂SO₄; AcOH / 1 h

2: Fe; AcOH / 1 h / 90 - 110 °C

3: tetrahydrofuran / 20 °C

4: 552 mg / K₂CO₃ / methanol / 0.5 h

5: 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

With dmap; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; 1: Nitration / 2: Reduction / 3: Acylation / 4: Deacetylation / 5: Acylation;
DOI:10.1021/jm9900063