6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester

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Chemical Name:6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester
CAS No.:136285-59-1
Molecular Formula:C₄₈H₄₄N₆O₅
Molecular Weight:784.915
Hs Code.:

Synonyms:6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester

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Chemical Property of 6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester

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Technology Process of 6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester

There total 4 articles about 6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 124750-51-2
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

: 136285-58-0
ethyl 6-methyl-3-nitro-2-valerylaminobenzoate

: 136285-59-1
6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 15h; Ambient temperature;
DOI:10.1021/jm00064a011

Reference yield:

: 638-29-9
n-valeryl chloride

: 136285-59-1
6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / triethylamine / CHCl₃ / 4 h / 0 °C

2: 52 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature

3: 80 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

With sulfuric acid; nitric acid; acetic anhydride; potassium carbonate; triethylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011

Reference yield:

: 90259-52-2
Ethyl 2-amino-6-methylbenzoate

: 136285-59-1
6-Methyl-3-nitro-2-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / triethylamine / CHCl₃ / 4 h / 0 °C

2: 52 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature

3: 80 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

With sulfuric acid; nitric acid; acetic anhydride; potassium carbonate; triethylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011