3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole

Base Information

Chemical Name:3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole
CAS No.:865787-09-3
Molecular Formula:C₂₀H₂₂N₄O₃
Molecular Weight:366.42
Hs Code.:

3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[<i>d</i>]isoxazole

Synonyms:3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole

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Chemical Property of 3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole

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Technology Process of 3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole

There total 3 articles about 3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 865787-03-7
1-(4-benzo[d]isoxazol-3-yl-piperazin-1-yl)-2-(4-methyl-2-nitro-phenyl)-ethanone

: 865787-09-3
3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole

Guidance literature:: With dimethylsulfide borane complex; In toluene; Heating;
DOI:10.1016/j.bmcl.2005.06.097

Reference yield:

: 622-47-9
4-tolylacetic acid

: 865787-09-3
3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / TFAA; NH₄NO₃ / CHCl₃

2: 50 percent / BOP-Cl; Et₃N / CH₂Cl₂

3: 49 percent / BH₃*SMe₂ / toluene / Heating

With ammonium nitrate; dimethylsulfide borane complex; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic anhydride; In dichloromethane; chloroform; toluene;
DOI:10.1016/j.bmcl.2005.06.097

Reference yield:

: 29640-90-2
(4-methyl-2-nitro-phenyl)-acetic acid

: 865787-09-3
3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / BOP-Cl; Et₃N / CH₂Cl₂

2: 49 percent / BH₃*SMe₂ / toluene / Heating

With dimethylsulfide borane complex; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.06.097