1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone

Base Information

• Chemical Name: 1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone
• CAS No.: 104720-61-8
• Molecular Formula: C₁₉H₂₂N₂O
• Molecular Weight: 294.396

Synonyms:1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone

Chemical Property of 1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone

Chemical Property:

Purity/Quality:

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Technology Process of 1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone

There total 1 articles about 1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + 1,2,3,4-tetrahydro-5,8-dimethylisoquinoline (104720-88-9) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone (104720-61-8) + 1-(7-Amino-5,8-dimethyl-6-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone (104720-62-9)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0040-4039(00)98934-2

Reference yield:

1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone (104720-61-8) → ellipticine (519-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NaNO₂/H⁺

2: NaN₃

3: Heating

4: 46 percent / 10 percent Pd-C / Heating

With sodium azide; hydrogen cation; sodium nitrite; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)98934-2

Reference yield:

1-(6-Amino-5,8-dimethyl-7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone (104720-61-8) → 2-Acetyl-5,8-dimethyl-7-phenyl-1,2,3,4-tetrahydro-isoquinoline-6-diazonium

Guidance literature:

With hydrogen cation; sodium nitrite;

DOI:10.1016/S0040-4039(00)98934-2

upstream raw materials:

acetic anhydride

1,2,3,4-tetrahydro-5,8-dimethylisoquinoline

benzene

Downstream raw materials:

ellipticine

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