(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

Base Information

Chemical Name:(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate
CAS No.:1390644-37-7
Molecular Formula:C₂₆H₃₅NO₃
Molecular Weight:409.569
Hs Code.:

Synonyms:(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

Suppliers and Price of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-5-HydroxymethylTolterodineMethacrylate
1mg
$ 195.00

Medical Isotopes, Inc.
(R)-5-HydroxymethylTolterodineMethacrylate
10 mg
$ 2400.00

Total 2 raw suppliers

Chemical Property of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

(R)-5-HydroxymethylTolterodineMethacrylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (R)-5-Hydroxymethyl Tolterodine Methacrylate is an impurity of (R)-Fesoterodine Fumarate (F321300), a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS). It is very similar to Tolterodine (T535800).

Technology Process of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

There total 26 articles about (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390644-38-8
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

: 1390644-37-7
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

Guidance literature:: With sodium carbonate; In water; at 25 - 30 ℃; pH=9.5;

Reference yield:

: 920-46-7,26937-45-1
Methacryloyl chloride

: 207679-81-0
(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

: 1390644-37-7
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

Guidance literature:: In chloroform; at -45 - -35 ℃; for 0.75h;

Reference yield:

: 621-82-9
Cinnamic acid

: 1390644-37-7
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; acetic acid / 16 h / 100 °C

2: acetone / 2 h / 25 - 35 °C

3: boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / -20 °C

4: hydrogen / 5%-palladium/activated carbon / methanol / 18 h / 25 - 35 °C / 2942.29 Torr / autoclave

5: potassium carbonate / acetone / 6 h / Reflux

6: chloroform / 0.75 h / -45 - -35 °C

With sulfuric acid; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; acetic acid; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; chloroform; acetone;