1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone

Base Information

Chemical Name:1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone
CAS No.:1263874-90-3
Molecular Formula:C₁₈H₂₃N₃OS
Molecular Weight:329.466
Hs Code.:

Synonyms:1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone

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Chemical Property of 1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone

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Technology Process of 1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone

There total 5 articles about 1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1263874-89-0
(2-{1-[2-(2,5-dimethyl-phenyl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-carbamic acid tert-butyl ester

: 1263874-90-3
1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone

Guidance literature:: (2-{1-[2-(2,5-dimethyl-phenyl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 72h;

With sodium hydrogencarbonate; In water; at 20 ℃; for 0.5h;

Reference yield:

: 721963-02-6
2-piperidine-4-yl-thiazole-4-carboxylic acid ethyl ester

: 1263874-90-3
1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

2.2: pH 2 - 3

3.1: triethylamine / 0.5 h / 20 °C

3.2: 0.25 h / 100 °C / Microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane / 72 h / 20 °C

4.2: 0.5 h / 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 3.2: Curtius Rearrangement;

Reference yield:

: 13612-34-5
2-(2,5-dimethylphenyl)acetic acid

: 1263874-90-3
1-[4-(4-amino-thiazol-2-yl)-piperidin-1-yl]-2-(2,5-dimethyl-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

2.2: pH 2 - 3

3.1: triethylamine / 0.5 h / 20 °C

3.2: 0.25 h / 100 °C / Microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane / 72 h / 20 °C

4.2: 0.5 h / 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 3.2: Curtius Rearrangement;