6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

Base Information

Chemical Name:6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one
CAS No.:1356353-49-5
Molecular Formula:C₁₄H₁₃BrF₃N₃O₂S
Molecular Weight:424.241
Hs Code.:

Synonyms:6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

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Chemical Property of 6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

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Technology Process of 6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

There total 7 articles about 6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356353-48-4
6-amino-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

: 1356353-49-5
6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

Guidance literature:: With bromine; sodium acetate; acetic acid; at 20 ℃; for 2h;

Reference yield:

: 1356353-46-2
6-[bis(2,4-dimethoxybenzyl)amino]-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrimidin-4(1H)-one

: 1356353-49-5
6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; acetonitrile / 2 h / 70 °C

2: trifluoroacetic acid / 1 h / 20 °C

3: sodium acetate; bromine; acetic acid / 2 h / 20 °C

With bromine; sodium acetate; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1356353-49-5
6-amino-5-bromo-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: hydrogen; palladium 10% on activated carbon / water; methanol / 24 h / 20 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 0.25 h / -5 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Cooling with ice

4.2: 0.5 h / Cooling with ice

5.1: sodium hydrogencarbonate / water; acetonitrile / 2 h / 70 °C

6.1: trifluoroacetic acid / 1 h / 20 °C

7.1: sodium acetate; bromine; acetic acid / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; bromine; sodium acetate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;