5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Base Information

Chemical Name:5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
CAS No.:1404065-32-2
Molecular Formula:C₁₉H₂₁N₅O₄
Molecular Weight:383.407
Hs Code.:

Synonyms:5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

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Chemical Property of 5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

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Technology Process of 5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

There total 5 articles about 5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1404065-20-8
4,5-diamino-2-cyclohexyl-6-methylpyridazin-3(2H)-one

: 136507-15-8
4-nitro-2-methoxybenzaldehyde

: 1404065-32-2
5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Guidance literature:: With sulfur; In 5,5-dimethyl-1,3-cyclohexadiene; at 160 - 170 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.07.077

Reference yield:

: 5157-08-4
3-methyl-4,5-dihydro-6-oxopyridazine

: 1404065-32-2
5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: bromine; acetic acid / 6 h / 90 °C

2: hydrazine hydrate / 16 h / 150 - 160 °C

3: nitric acid; sulfuric acid / 3 h / 0 - 20 °C

4: sulfuric acid / 5 h / 55 - 60 °C

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 - 110 °C

6: acetic acid; iron / 12 h / Reflux

7: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 160 - 170 °C

With sulfuric acid; bromine; nitric acid; iron; potassium carbonate; sulfur; hydrazine hydrate; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.077

Reference yield:

: 13925-21-8
4-amino-6-methylpyridazin-3(2H)-one

: 1404065-32-2
5-cyclohexyl-2-(2-methoxy-4-nitrophenyl)-7-methyl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; sulfuric acid / 3 h / 0 - 20 °C

2: sulfuric acid / 5 h / 55 - 60 °C

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 - 110 °C

4: acetic acid; iron / 12 h / Reflux

5: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 160 - 170 °C

With sulfuric acid; nitric acid; iron; potassium carbonate; sulfur; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.077