N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine

Base Information

• Chemical Name: N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine
• CAS No.: 1160624-49-6
• Molecular Formula: C₃₁H₂₅F₃N₆O₂S
• Molecular Weight: 602.64
• Mol file: 1160624-49-6.mol

Synonyms:N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine

Chemical Property of N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine

There total 1 articles about N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-(2-chloro-4-pyrimidinyl)-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-2-amine (1160624-46-3) + 1-(7-amino-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one (181634-14-0) → N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine (1160624-49-6)

Guidance literature:

5-(2-chloro-4-pyrimidinyl)-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-2-amine; 1-(7-amino-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one; With hydrogenchloride; In N,N-dimethyl acetamide; water; isopropyl alcohol; at 70 ℃; for 48h;

With water; sodium hydrogencarbonate; In N,N-dimethyl acetamide; isopropyl alcohol;

Reference yield: 32.0%

N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinamine (1160624-49-6) → N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-1,2,3,4-tetrahydro-7-isoquinolinamine (1160624-48-5)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; at 20 - 50 ℃; for 3h;

upstream raw materials:

5-(2-chloro-4-pyrimidinyl)-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-2-amine

1-(7-amino-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one

Downstream raw materials:

N-(4-(2-amino-4-(3-((phenylmethyl)oxy)phenyl)-1,3-thiazol-5-yl)-2-pyrimidinyl)-1,2,3,4-tetrahydro-7-isoquinolinamine