6-tert-butyl-3-bromo-2,4-diphenyl chroman

Base Information

• Chemical Name: 6-tert-butyl-3-bromo-2,4-diphenyl chroman
• CAS No.: 1321621-09-3
• Molecular Formula: C₂₅H₂₅BrO
• Molecular Weight: 421.377
• Mol file: 1321621-09-3.mol

Synonyms:6-tert-butyl-3-bromo-2,4-diphenyl chroman

Chemical Property of 6-tert-butyl-3-bromo-2,4-diphenyl chroman

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-tert-butyl-3-bromo-2,4-diphenyl chroman

There total 2 articles about 6-tert-butyl-3-bromo-2,4-diphenyl chroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-tert-butyl-2-(1,3-diphenylallyl)phenol → 6-tert-butyl-3-bromo-2,4-diphenyl chroman (1321621-09-3)

Guidance literature:

With copper(ll) bromide; In acetonitrile; at 20 ℃; for 0.0833333h; diastereoselective reaction;

DOI:10.1055/s-0030-1260795

Reference yield:

para-tert-butylphenol (98-54-4) + 1,3-diphenyl-3-hydroxypropene (4663-33-6,62668-02-4,62839-70-7,116127-91-4,132014-29-0,136981-81-2,148616-45-9) → 6-tert-butyl-3-bromo-2,4-diphenyl chroman (1321621-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: antimony(III) chloride / acetonitrile / 0.42 h / 65 °C / Microwave irradiation

1.2: -20 - 0 °C

2.1: copper(ll) bromide / acetonitrile / 0.08 h / 20 °C

With antimony(III) chloride; copper(ll) bromide; In acetonitrile;

DOI:10.1055/s-0030-1260795

upstream raw materials:

para-tert-butylphenol

1,3-diphenyl-3-hydroxypropene