4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate

Base Information

• Chemical Name: 4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate
• CAS No.: 125440-23-5
• Molecular Formula: C₃₃H₃₅Br₂N₄O₁₄PS
• Molecular Weight: 934.507

Synonyms:4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate

Chemical Property of 4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate

Chemical Property:

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Technology Process of 4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate

There total 2 articles about 4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-(methylthio)phenyl phosphorodichloridate (53676-21-4) + (E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridine (84218-88-2) → 4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate (125440-23-5)

Guidance literature:

With 1-methyl-1H-imidazole; In acetonitrile; for 20h; Ambient temperature;

DOI:10.1021/jm00167a019

Reference yield:

4-hydroxythioanisole (1073-72-9) → 4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate (125440-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / phosphoryl chloride, 1-methylimidazole / 20 h / Heating

2: 55 percent / 1-methylimidazole / acetonitrile / 20 h / Ambient temperature

With 1-methyl-1H-imidazole; trichlorophosphate; In acetonitrile;

DOI:10.1021/jm00167a019

Reference yield: 70.0%

4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate (125440-23-5) → 4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-2'-deoxyuridin-5'-yl> phosphate (125440-26-8)

Guidance literature:

With potassium carbonate; In methanol; water; Ambient temperature;

DOI:10.1021/jm00167a019

upstream raw materials:

4-(methylthio)phenyl phosphorodichloridate

(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridine

4-hydroxythioanisole

Downstream raw materials:

4-(methylthio)phenyl bis<(E)-5-(2-bromovinyl)-2'-deoxyuridin-5'-yl> phosphate

4-(methylsulfonyl)phenyl bis<(E)-5-(2-bromovinyl)-3'-O-acetyl-2'-deoxyuridin-5'-yl> phosphate

4-(methylsulfonyl)phenyl bis<(E)-5-(2-bromovinyl)-2'-deoxyuridin-5'-yl> phosphate

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