C₉H₈BrNO

Base Information

• Chemical Name: C₉H₈BrNO
• CAS No.: 1269411-23-5
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.073
• Mol file: 1269411-23-5.mol

Synonyms:C₉H₈BrNO

Chemical Property of C₉H₈BrNO

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₈BrNO

There total 6 articles about C₉H₈BrNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H6BrNO (1269411-22-4) → C9H8BrNO (1269411-23-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2010.12.034

Reference yield:

2-bromo-3-(bromomethyl)benzonitrile (1086429-87-9) → C9H8BrNO (1269411-23-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 1 h / 80 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 1 h / 20 °C

3.1: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

4.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C

4.2: 16 h / 0 - 20 °C

5.1: hydrogenchloride / tetrahydrofuran; water / 1 h / Reflux

6.1: sodium tetrahydroborate / methanol / 20 °C

With hydrogenchloride; sodium tetrahydroborate; potassium tert-butylate; silica gel; pyridinium chlorochromate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 4.2: Wittig reaction;

DOI:10.1016/j.bmcl.2010.12.034

Reference yield:

C8H6BrNO (1086429-88-0) → C9H8BrNO (1269411-23-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

2.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C

2.2: 16 h / 0 - 20 °C

3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / Reflux

4.1: sodium tetrahydroborate / methanol / 20 °C

With hydrogenchloride; sodium tetrahydroborate; potassium tert-butylate; silica gel; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; 2.2: Wittig reaction;

DOI:10.1016/j.bmcl.2010.12.034

upstream raw materials:

2-bromo-3-(bromomethyl)benzonitrile

C₈H₆BrNO

2-bromo-3-cyanobenzaldehyde

C₁₀H₈BrNO

Downstream raw materials:

C₁₇H₂₂BNO₄

C₁₁H₁₀BrNO₂

Refernces