(2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid

Base Information

Chemical Name:(2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid
CAS No.:276888-52-9
Molecular Formula:C₁₅H₂₇NO₅
Molecular Weight:301.383
Hs Code.:

Synonyms:(2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid

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Chemical Property of (2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid

Chemical Property:

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Technology Process of (2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid

There total 8 articles about (2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 113785-82-3,121506-22-7,126832-05-1,140409-01-4
(3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

: 77-92-9,906507-37-7
citric acid

: 276888-52-9
(2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid

Guidance literature:: With triethylamine; In 1,4-dioxane; water;

Reference yield:

: 1046536-28-0
C₁₆H₂₉NO₅

: 276888-52-9
(2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid

Guidance literature:: C₁₆H₂₉NO₅; With lithium hydroxide; water; In tetrahydrofuran; methanol; for 0.25h;

With sodium hydrogen sulfate; In tetrahydrofuran; methanol; water;

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 276888-52-9
(2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / TFA; pyridine / 0 - 20 °C

2: aq. HCl / Heating

3: aq. K₂CO₃ / dioxane

With pyridine; hydrogenchloride; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; 1: Passerini reaction / 2: acidolysis / 3: Acylation;
DOI:10.1016/S0960-894X(00)00458-3