(R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide

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Chemical Name:(R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide
CAS No.:1053651-90-3
Molecular Formula:C₂₇H₄₅N₅O₅
Molecular Weight:519.685
Hs Code.:

Synonyms:(R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide

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Chemical Property of (R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide

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Technology Process of (R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide

There total 8 articles about (R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181038-69-7
[(S)-1-((1S,2R)-1-Benzyl-3-{(R)-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyrylamino}-2-hydroxy-propylcarbamoyl)-2-carbamoyl-ethyl]-carbamic acid benzyl ester

: 1053651-90-3
(R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; under 760 Torr;
DOI:10.1021/jm9606608

Reference yield:

: 5671-87-4
tert-butyl-succinic acid

: 1053651-90-3
(R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 7 steps

2: 95 percent / Ac₂O / 5 h / 100 °C

3: 75 percent / pyridine / Ambient temperature

4: benzotriazol-1-yl-1,1,3,3-tetramethyluronium tetrafluoroborate, N-methylmorpholine / dimethylformamide

5: 4N HCl/dioxane

6: benzotriazol-1-yl-1,1,3,3-tetramethyluronium tetrafluoroborate, N-methylmorpholine / dimethylformamide

7: H₂ / 20percent Pd(OH)2/C / methanol / 760 Torr

With 4-methyl-morpholine; pyridine; hydrogenchloride; hydrogen; acetic anhydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium dihydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9606608

Reference yield:

: 59322-59-7
2-tert-butyl-butanedioic acid diethyl ester

: 1053651-90-3
(R)-N-[(2R,3S)-3-((S)-2-Amino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-2-[(1-ethyl-propylcarbamoyl)-methyl]-3,3-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / conc. aq. HCl / Heating

3: 95 percent / Ac₂O / 5 h / 100 °C

4: 75 percent / pyridine / Ambient temperature

5: benzotriazol-1-yl-1,1,3,3-tetramethyluronium tetrafluoroborate, N-methylmorpholine / dimethylformamide

6: 4N HCl/dioxane

7: benzotriazol-1-yl-1,1,3,3-tetramethyluronium tetrafluoroborate, N-methylmorpholine / dimethylformamide

8: H₂ / 20percent Pd(OH)2/C / methanol / 760 Torr

With 4-methyl-morpholine; pyridine; hydrogenchloride; hydrogen; acetic anhydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium dihydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9606608