3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide

Base Information

Chemical Name:3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide
CAS No.:1336908-63-4
Molecular Formula:C₂₃H₂₉FN₂O₂
Molecular Weight:384.494
Hs Code.:

Synonyms:3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide

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Chemical Property of 3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide

Chemical Property:

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Technology Process of 3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide

There total 4 articles about 3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-41-5
4-Fluorophenol

: 1336910-42-9
3-bromo-N-(1-isopropylpiperidin-3-ylmethyl)-4-methylbenzamide

: 1336908-63-4
3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide

Guidance literature:: With N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 102297-41-6
3-<amino>methyl>pyridine

: 1336908-63-4
3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / Rh/Al₂O₃ / methanol / 16 h / 50 °C / 30003 Torr

2.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h

2.2: pH ~ 14

3.1: trifluoroacetic acid / dichloromethane / 18 h / 0 °C

3.2: pH ~ 14

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h

4.2: 16 h

5.1: caesium carbonate; N,N-dimethylglycine hydrochoride / copper(l) iodide / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere; Sealed tube

With hydrogen; N,N-dimethylglycine hydrochoride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; copper(l) iodide; Rh/Al₂O₃; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1336910-17-8
(1-isopropylpiperidin-3-ylmethyl)carbamic acid tert-butyl ester

: 1336908-63-4
3-(4-fluorophenoxy)-N-(1-isopropylpiperidin-3-ylmethyl)-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 18 h / 0 °C

1.2: pH ~ 14

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h

2.2: 16 h

3.1: caesium carbonate; N,N-dimethylglycine hydrochoride / copper(l) iodide / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere; Sealed tube

With N,N-dimethylglycine hydrochoride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; copper(l) iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;