2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine

Base Information

Chemical Name:2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine
CAS No.:337902-88-2
Molecular Formula:C₂₁H₂₄FN₅O₂
Molecular Weight:397.452
Hs Code.:

Synonyms:2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine

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Technology Process of 2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine

There total 4 articles about 2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

: 337902-88-2
2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine

Guidance literature:

Reference yield: 70.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 337902-87-1
2-(4-fluoro-phenyl)-5-piperazin-1-yl-1H-imidazo[4,5-b]pyridine

: 337902-88-2
2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine

Guidance literature:: With sodium carbonate; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2004.03.106

Reference yield:

: 337902-85-9
5-Nitro-6-amino-2-(4-ethoxycarbonyl-1-piperazinyl)pyridine

: 337902-88-2
2-(4-Fluorophenyl)-5-(4-tert.butoxycarbonyl-1-piperazinyl)imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / H₂ / Pd/C / ethanol

2: 55 percent / polyphosphoric acid / 130 - 150 °C

3: 70 percent / Na₂CO₃ / ethyl acetate / 2 h / 20 °C

With PPA; hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1016/j.bmcl.2004.03.106