4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide

Base Information

• Chemical Name: 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide
• CAS No.: 150726-86-6
• Molecular Formula: C₂₂H₂₄ClN₃O₄S
• Molecular Weight: 461.969
• Mol file: 150726-86-6.mol

Synonyms:4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide

Chemical Property of 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide

There total 4 articles about 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert.-butylbenzene sulfonamide potassium salt + 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine (150726-83-3) → 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide (150726-86-6)

Guidance literature:

With acetic acid; In water; dimethyl sulfoxide;

Reference yield:

4-tert-butylbenzenesulphonamide (6292-59-7) + 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine (150726-83-3) → 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide (150726-86-6)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃;

DOI:10.1016/S0960-894X(01)00682-5

Reference yield:

2-(2-Methoxyphenoxy)propanedioic acid diethyl ester (20730-58-9) → 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide (150726-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOMe / methanol / 20 °C

2: POCl₃ / Heating

3: K₂CO₃ / dimethylsulfoxide / 80 °C

With sodium methylate; potassium carbonate; trichlorophosphate; In methanol; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(01)00682-5

upstream raw materials:

4-tert-butylbenzenesulphonamide

4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine

2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

5-(o-methoxyphenoxy)-4,6-dihydroxy-2-methyl-pyrimidine

Downstream raw materials:

p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxy-phenoxy)-2-methyl-4-pyrimidinyl]benzenesulfonamide