N^α-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester

Base Information

• Chemical Name: N^α-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester
• CAS No.: 108744-21-4
• Molecular Formula: C₃₇H₄₇N₇O₉
• Molecular Weight: 733.822

Synonyms:N^α-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester

Chemical Property of N^α-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester

Chemical Property:

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Technology Process of N^α-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester

There total 1 articles about N^α-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Nα-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester (13798-75-9) + xanthine amine congener (96865-92-8) → Nα-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester (108744-21-4)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1021/jm00391a046

Reference yield:

Nα-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester (108744-21-4) → (S)-3-tert-Butoxycarbonylamino-N-(2-{2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-ethyl)-succinamic acid (108744-22-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1021/jm00391a046

Reference yield:

Nα-(tert-butyloxycarbonyl)-α-L-aspartyl-8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthine β-benzyl ester (108744-21-4) → α-(tert-butyloxycarbonyl)-α-aspartyl<8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthin-4.2-yl>>-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methionine amide (108744-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / dimethylformamide

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDAC), 1-hydroxybenzotriazole (HOBt) / dimethylformamide / 0.25 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1021/jm00391a046

upstream raw materials:

N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

xanthine amine congener

Downstream raw materials:

(S)-3-tert-Butoxycarbonylamino-N-(2-{2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-ethyl)-succinamic acid

α-(tert-butyloxycarbonyl)-α-aspartyl<8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthin-4.2-yl>>-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methionine amide

<α-aspartyl<8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthin-4.2-yl>>-L-phenylalanyl-L-phenylalanylglycine amide trifluoroacetate

<α-aspartyl<8-<4-<<<<(aminoethyl)amino>carbonyl>methyl>oxy>phenyl>-1,3-dipropylxanthin-4.2-yl>>-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methionine amide trifluoroacetate

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