4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

Base Information

Chemical Name:4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid
CAS No.:1204422-39-8
Molecular Formula:C₂₁H₂₄N₄O₃
Molecular Weight:380.447
Hs Code.:

Synonyms:4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

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Chemical Property of 4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

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Technology Process of 4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

There total 5 articles about 4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1204423-75-5
4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid benzyl ester

: 1204422-39-8
4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 5h;

Reference yield:

: 669-32-9
5-ethyl-4-phenyl-1H-imidazole

: 1204422-39-8
4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetra-(n-butyl)ammonium iodide / acetonitrile / 70 °C

2: sodium hydroxide; water / ethanol / 1 h

3: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C

With water; hydrogen; potassium carbonate; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; tetra-(n-butyl)ammonium iodide; In ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 103030-67-7
Chlorhydrate d'α-aminobutyrophenone

: 1204422-39-8
4-{3-(4-Phenyl-5-ethylimidazol-1-yl)propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol; water / 1 h / 70 °C

1.2: 3 h / 100 °C

1.3: Raney Ni / 2 h / 70 °C

2.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / acetonitrile / 70 °C

3.1: sodium hydroxide; water / ethanol / 1 h

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C

With hydrogenchloride; water; hydrogen; potassium carbonate; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; tetra-(n-butyl)ammonium iodide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;