methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate

Base Information

Chemical Name:methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate
CAS No.:200400-62-0
Molecular Formula:C₁₇H₁₄N₂O₄
Molecular Weight:310.309
Hs Code.:

Synonyms:methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate

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Chemical Property of methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate

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Technology Process of methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate

There total 7 articles about methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 200400-61-9
N-<4-(3-pyridylcarbonyl)benzoyl>-DL-serine methyl ester

: 200400-62-0
methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate

Guidance literature:: With potassium phosphate; trifluoromethylsulfonic anhydride; 1,1'-sulfinylbisbenzene; In dichloromethane; at -78 - 0 ℃; for 2h;
DOI:10.1016/S0960-894X(98)00353-9

Reference yield:

: 89667-30-1
methyl 4-(3-pyridylcarbonyl)benzoate

: 200400-62-0
methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.0N aq. NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

2: 81 percent / HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16.5 h / 0 - 20 °C

3: 65 percent / (TfO)2O, K₃PO₄, Ph₂SO / CH₂Cl₂ / 1 h / -78 - 0 °C

With 4-methyl-morpholine; sodium hydroxide; potassium phosphate; trifluoromethylsulfonic anhydride; 1,1'-sulfinylbisbenzene; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980173n

Reference yield:

: 200400-36-8
4-(3-pyridylcarbonyl)benzoic acid

: 200400-62-0
methyl 4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16.5 h / 0 - 20 °C

2: 65 percent / (TfO)2O, K₃PO₄, Ph₂SO / CH₂Cl₂ / 1 h / -78 - 0 °C

With 4-methyl-morpholine; potassium phosphate; trifluoromethylsulfonic anhydride; 1,1'-sulfinylbisbenzene; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980173n