tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate
CAS No.:893442-84-7
Molecular Formula:C₂₈H₄₁NO₃Si
Molecular Weight:467.724
Hs Code.:

Synonyms:tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

Suppliers and Price of tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

There total 11 articles about tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 893429-94-2
(S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 893442-84-7
tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1271/bbb.69.1589

Reference yield:

: 893429-86-2
(S)-5-azido-7-(tert-butyldiphenylsilyloxy)heptanal

: 893442-84-7
tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / NaClO₂; 2-methyl-2-butene; NaH₂PO₄*2H₂O / H₂O; 2-methyl-propan-2-ol / 1 h / cooling

2: H₂ / Pd(OH)2/C / ethanol / 4 h / 20 °C

3: 4.29 g / toluene / 1 h / Heating

4: 48 percent / DIBAL-H / CH₂Cl₂; toluene / 1 h / 0 °C

5: 97 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; diisobutylaluminium hydride; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1271/bbb.69.1589

Reference yield:

: 893429-88-4
(S)-5-azido-7-(tert-butyldiphenylsilyloxy)heptanoic acid

: 893442-84-7
tert-butyl (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd(OH)2/C / ethanol / 4 h / 20 °C

2: 4.29 g / toluene / 1 h / Heating

3: 48 percent / DIBAL-H / CH₂Cl₂; toluene / 1 h / 0 °C

4: 97 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

With hydrogen; diisobutylaluminium hydride; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1271/bbb.69.1589