1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone

Base Information

Chemical Name:1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone
CAS No.:753452-00-5
Molecular Formula:C₁₉H₂₃NO₂
Molecular Weight:297.397
Hs Code.:

Synonyms:1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone

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Chemical Property of 1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone

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Technology Process of 1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone

There total 8 articles about 1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 753451-95-5
(3S,4R)-N-allyl-N-[(3-benzoxymethyl)-1,6-heptadien-4-yl]propenamide

: 1-((1R,2S)-2-Benzyloxymethyl-cyclopent-3-enyl)-1,5-dihydro-pyrrol-2-one

: (9S,9aR)-9-Benzyloxymethyl-1,6,9,9a-tetrahydro-quinolizin-4-one

: 753452-00-5
1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; for 52h; Heating;
DOI:10.1002/chem.200305581

Reference yield:

: 753451-96-6
(2R,3S)-3-hydroxy-2-vinylhex-5-en-1-ol

: 753452-00-5
1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / -78 - 20 °C

2.1: 93 percent / Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

3.1: NaN₃ / hexamethylphosphoric acid triamide / 2 h / 40 °C

3.2: 94 percent / TBAF / tetrahydrofuran

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: 97 percent / tetrahydrofuran / 3.5 h / 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

6.1: 1.48 g / K₂CO₃ / dimethylformamide / 1.5 h / 0 - 20 °C

7.1: 90 percent / Et₃N / CH₂Cl₂ / -78 - 20 °C

8.1: 66 percent / Cl₂Ru(PCy₃)2=CHPh / CH₂Cl₂ / 52 h / Heating

With dmap; lithium aluminium tetrahydride; sodium azide; sodium hydride; potassium carbonate; triethylamine; Grubbs catalyst first generation; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200305581

Reference yield:

: 753452-12-9
(1R,2S)-1-Allyl-2-benzyloxymethyl-but-3-enylamine

: 753452-00-5
1-[(R)-2-((S)-1-Benzyloxymethyl-allyl)-3,6-dihydro-2H-pyridin-1-yl]-propenone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.48 g / K₂CO₃ / dimethylformamide / 1.5 h / 0 - 20 °C

2: 90 percent / Et₃N / CH₂Cl₂ / -78 - 20 °C

3: 66 percent / Cl₂Ru(PCy₃)2=CHPh / CH₂Cl₂ / 52 h / Heating

With potassium carbonate; triethylamine; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200305581