Technology Process of N-<7-<(phenylmethyl)amino>-1,2,3,4-tetrahydro-9H-carbazol-3-yl>acetamide
There total 5 articles about N-<7-<(phenylmethyl)amino>-1,2,3,4-tetrahydro-9H-carbazol-3-yl>acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2 / Raney nickel / ethanol / 3 h / 180 °C / 90500.9 Torr
2: 72 percent / sodium dichromate dihydrate, conc. H2SO4 / H2O / 0.33 h
3: 85 percent / toluene / 3 h / Heating
4: 2.) 3.5percent aq. HCl / 1.) CH2Cl2, RT, 24 h, 2.) 24 h
5: 92.5 percent / H2 / 10percent Pd/C / acetic acid / 3 h / 760 Torr / Ambient temperature
6: 1.) acetic acid, sodium acetate trihydrate, 2.) sodium cyanoborohydride / 1.) ethanol, H2O, RT, 10 min, 2.) ethanol, H2O, RT, 15 min
With
hydrogenchloride; sodium dichromate; sulfuric acid; hydrogen; sodium acetate; sodium cyanoborohydride; acetic acid;
palladium on activated charcoal; nickel;
In
ethanol; water; acetic acid; toluene;
DOI:10.1021/jm00158a022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / toluene / 3 h / Heating
2: 2.) 3.5percent aq. HCl / 1.) CH2Cl2, RT, 24 h, 2.) 24 h
3: 92.5 percent / H2 / 10percent Pd/C / acetic acid / 3 h / 760 Torr / Ambient temperature
4: 1.) acetic acid, sodium acetate trihydrate, 2.) sodium cyanoborohydride / 1.) ethanol, H2O, RT, 10 min, 2.) ethanol, H2O, RT, 15 min
With
hydrogenchloride; hydrogen; sodium acetate; sodium cyanoborohydride; acetic acid;
palladium on activated charcoal;
In
acetic acid; toluene;
DOI:10.1021/jm00158a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / sodium dichromate dihydrate, conc. H2SO4 / H2O / 0.33 h
2: 85 percent / toluene / 3 h / Heating
3: 2.) 3.5percent aq. HCl / 1.) CH2Cl2, RT, 24 h, 2.) 24 h
4: 92.5 percent / H2 / 10percent Pd/C / acetic acid / 3 h / 760 Torr / Ambient temperature
5: 1.) acetic acid, sodium acetate trihydrate, 2.) sodium cyanoborohydride / 1.) ethanol, H2O, RT, 10 min, 2.) ethanol, H2O, RT, 15 min
With
hydrogenchloride; sodium dichromate; sulfuric acid; hydrogen; sodium acetate; sodium cyanoborohydride; acetic acid;
palladium on activated charcoal;
In
water; acetic acid; toluene;
DOI:10.1021/jm00158a022
