3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one

Base Information

Chemical Name:3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one
CAS No.:212143-70-9
Molecular Formula:C₂₁H₁₉BrClN₅O
Molecular Weight:472.772
Hs Code.:

Synonyms:3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one

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Chemical Property of 3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one

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Technology Process of 3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one

There total 3 articles about 3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.7%

: 41202-32-8,55974-33-9,76835-05-7
1-(2-chlorophenyl)piperazine hydrochloride

: 212143-68-5
3-Bromo-2-bromomethyl-6H-imidazo[1,2-c]quinazolin-5-one

: 212143-70-9
3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; for 24h; Heating;
DOI:10.1021/jm970159v

Reference yield:

: 149847-72-3
2-Methyl-6H-imidazo[1,2-c]quinazolin-5-one

: 212143-70-9
3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 91.6 percent / AIBN, NBS / 1,2-dichloro-ethane; CCl₄ / 48 h / Ambient temperature

2: 44.7 percent / NaHCO₃ / acetonitrile / 24 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; In tetrachloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm970159v

Reference yield:

: 2-Bromomethyl-5-methylsulfanyl-2,3-dihydro-imidazo[1,2-c]quinazoline

: 212143-70-9
3-Bromo-2-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-6H-imidazo[1,2-c]quinazolin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 2 h / 90 °C

2: 91.6 percent / AIBN, NBS / 1,2-dichloro-ethane; CCl₄ / 48 h / Ambient temperature

3: 44.7 percent / NaHCO₃ / acetonitrile / 24 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; potassium carbonate; In tetrachloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970159v