N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine

Base Information

Chemical Name:N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine
CAS No.:205874-99-3
Molecular Formula:C₄₀H₄₈N₆O₇S
Molecular Weight:756.923
Hs Code.:

N-(N<sup>α</sup>-benzyloxycarbonyl-N<sup>α</sup>-methyl-O-benzyltyrosyl-N<sup>g</sup>-tosylarginyl)ethanamine

Synonyms:N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine

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Technology Process of N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine

There total 4 articles about N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86827-18-1,92455-53-3,16677-29-5
N-benzyloxycarbonyl-O-benzyl-L-tyrosine

: 205874-99-3
N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: 78.3 percent / NaH / tetrahydrofuran / 0 - 20 °C

2: 752 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / dimethylformamide / 0 - 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Methylation / 2: Acylation;
DOI:10.1246/bcsj.71.699

Reference yield:

: 95015-69-3
N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosine

: H-Arg(Ts)-NHEt

: 205874-99-3
N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1246/bcsj.71.699

Reference yield:

: 13836-37-8
Boc-Arg(Tos)-OH

: 205874-99-3
N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: 90.8 percent / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N,N-diisopropylethylamine / dimethylformamide / 0 - 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 20 °C

3: 752 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / dimethylformamide / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: deprotection / 3: Acylation;
DOI:10.1246/bcsj.71.699