ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate

Base Information

Chemical Name:ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate
CAS No.:755757-52-9
Molecular Formula:C₃₃H₃₄N₂O₆
Molecular Weight:554.643
Hs Code.:

Synonyms:ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate

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Chemical Property of ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate

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Technology Process of ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate

There total 7 articles about ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2969-81-5
Ethyl 4-bromobutyrate

: 448956-64-7
3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenol

: 755757-52-9
ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2004.06.023

Reference yield:

: 102-29-4
Resorcinol monoacetate

: 755757-52-9
ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 57 percent / K₂CO₃ / dimethylformamide / 12 h / 80 °C

2: aq. NaOH / tetrahydrofuran; methanol / 1 h / 20 °C

3: K₂CO₃ / dimethylformamide / 12 h / 100 °C

4: AcOH / 1,2-dichloro-ethane / 4 h / 20 °C

5: Na(OAc)3BH / 1,2-dichloro-ethane / 12 °C

6: 84 percent / i-Pr₂NEt / dimethylformamide / 12 h / 90 °C

7: 96 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂ / 1 h / 20 °C

8: 69 percent / NaH / dimethylformamide / 12 h / 0 - 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.023

Reference yield:

: 1616-51-9
3-allyloxyphenol

: 755757-52-9
ethyl 4-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide / 12 h / 100 °C

2: AcOH / 1,2-dichloro-ethane / 4 h / 20 °C

3: Na(OAc)3BH / 1,2-dichloro-ethane / 12 °C

4: 84 percent / i-Pr₂NEt / dimethylformamide / 12 h / 90 °C

5: 96 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂ / 1 h / 20 °C

6: 69 percent / NaH / dimethylformamide / 12 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.023