2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

Base Information

Chemical Name:2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester
CAS No.:878674-22-7
Molecular Formula:C₂₄H₂₇FO₉
Molecular Weight:478.471
Hs Code.:

Synonyms:2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

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Chemical Property of 2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

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Technology Process of 2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

There total 1 articles about 2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878673-54-2
2-[3-bromo-5-formyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-succinic acid dimethyl ester

: 179897-94-0
(5-fluoro-2-methoxyphenyl)boronic acid

: 878674-22-7
2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

Guidance literature:: With tris(triphenylphosphano)palladium; In 1,2-dimethoxyethane; Heating;
DOI:10.1016/j.bmcl.2006.01.037

Reference yield: 90.0%

: 878674-22-7
2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

: 3,4-diaminobenzamidine monohydrochloride

: 878674-71-6
2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-fluoro-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

Guidance literature:: With p-benzoquinone; In methanol; for 6h; Heating;
DOI:10.1016/j.bmcl.2005.12.040

Reference yield:

: 878674-22-7
2-[5'-fluoro-5-formyl-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

: 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-fluoro-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: benzoquinone / methanol / Heating

2: aq. HBr / 100 °C

With hydrogen bromide; p-benzoquinone; In methanol;
DOI:10.1016/j.bmcl.2006.01.037