N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid

Base Information

• Chemical Name: N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid
• CAS No.: 176851-44-8
• Molecular Formula: C₂₀H₂₄N₂O₆
• Molecular Weight: 388.42
• Mol file: 176851-44-8.mol

Synonyms:N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid

Chemical Property of N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid

There total 1 articles about N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl chloroformate (501-53-1,94274-21-2) + midodrine hydrochloride (133163-28-7,3092-17-9,43218-56-0) → N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid (176851-44-8)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; for 4h;

DOI:10.1007/bf00807396

Reference yield:

N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid (176851-44-8) → (S)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

Multi-step reaction with 3 steps

1: p-TsOH / CH₂Cl₂ / 1 h

2: 86 percent / H₂ / Pd/C / methanol / 5 h / 3620.04 Torr

3: 76 percent / HCl / methanol; diethyl ether / 0.02 h / 0 °C

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;

DOI:10.1007/bf00807396

Reference yield:

N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((phenylmethoxy)carbonylamino)essigsaeureamid (176851-44-8) → (R)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

Multi-step reaction with 3 steps

1: p-TsOH / CH₂Cl₂ / 1 h

2: 80 percent / H₂ / Pd/C / methanol / 5 h / 3620.04 Torr

3: 83 percent / HCl / methanol; diethyl ether / 0.02 h / 0 °C

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;

DOI:10.1007/bf00807396

upstream raw materials:

benzyl chloroformate

midodrine hydrochloride

Downstream raw materials:

{[(S)-2-(2,5-Dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-ethylcarbamoyl]-methyl}-carbamic acid benzyl ester

{[(R)-2-(2,5-Dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-ethylcarbamoyl]-methyl}-carbamic acid benzyl ester

(S)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid

(R)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid