[4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester

Base Information

• Chemical Name: [4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester
• CAS No.: 137860-14-1
• Molecular Formula: C₁₈H₂₀F₃N₃O₅
• Molecular Weight: 415.369

Synonyms:[4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester

Chemical Property of [4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester

Chemical Property:

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Technology Process of [4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester

There total 4 articles about [4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl butyroyl acetate (3249-68-1) → [4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester (137860-14-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / diisopropylethylamine, LiCl / tetrahydrofuran / 15 h / Heating

2: 82 percent / ethanol / 3 h / Heating

3: Na₂CO₃ / acetone / 10 h / Heating

With sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; ethanol; acetone;

DOI:10.1248/cpb.42.1617

Reference yield:

ethyl 2-(4-nitrobenzyl)-3-oxohexanoate (137860-00-5) → [4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester (137860-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / ethanol / 3 h / Heating

2: Na₂CO₃ / acetone / 10 h / Heating

With sodium carbonate; In ethanol; acetone;

DOI:10.1248/cpb.42.1617

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) → [4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester (137860-14-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / diisopropylethylamine, LiCl / tetrahydrofuran / 15 h / Heating

2: 82 percent / ethanol / 3 h / Heating

3: Na₂CO₃ / acetone / 10 h / Heating

With sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; ethanol; acetone;

DOI:10.1248/cpb.42.1617

upstream raw materials:

bromoacetic acid methyl ester

4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-ol

ethyl butyroyl acetate

ethyl 2-(4-nitrobenzyl)-3-oxohexanoate

Downstream raw materials:

[4-(4-Amino-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yloxy]-acetic acid methyl ester

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